Finding the Genes for Gout: The effect of frusemide
Kia OraWe invite you to take part in a study looking into the causes of high uric acid levels and gout.
We are looking for healthy volunteers of NZ European, Maori and/or Pacific Island origin between the ages of 18 and 50. The study is intended to find out how our genes might influence the ability of frusemide (a medication used to treat fluid retention) to increase blood uric acid levels.
The study involves two visits to the Clinical Research Centre at the University of Auckland Grafton Campus.
After an initial screening visit you may be invited along to the second visit which you will be given a single tablet of frusemide (a medication used to treat fluid retention) and your blood and urine will be collected over a three hour period.
Your travel costs will be covered and we will provide you with a $100 voucher at the end of the second visit.
This study has ethical approval.
FilesPIS frusemide substudy March 2014 use
Healthy volunteers included
Inclusion Criteria Are you between (and including) 18 and 50 years of age? Exclusion Criteria History of gout History of diabetes Currently taking a diuretic History of recurrent vasovagal syncope/fainting History of intolerance to furosemide If during the second visit your fasting capillary glucose is > 6.0 mmol/L We do a blood test during the screening visit to determine biochemical eligibility for: Serum potassium (exclude if < 3.5mmol/L) eGFR (exclude if < 60)