Effect of long-distance running on the ankle and knee joints

Archived Expires 31 December, 2017
This study is not currently open to accept applicants.
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Long-distance running such as marathons and Ironman competitions have become popular fitness activities, even for amateurs. Despite its obvious health benefits, however, repetitive and excessive loading imposed on the knee and ankle joints resulting from long-distance running may cause cartilage or ligament damage. This leads to onset of osteoarthritis, increased subsequent health care costs due to knee therapy, implants or lost work days. Thus, an appreciation of biomechanics for endurance running in the ankle and knee joint is of great value for both injury prevention and treatment.

This investigation can be accomplished using 3D anatomically-based computational models, representing personalised joint geometry, combined with modern image techniques including MR, CT and functional diffusion imaging such as PET-CT. A better understanding of the ankle and knee joint can provide possible aetiology of joint injury, explanation of pathology and inform better diagnostic techniques. Such information can be also used to develop novel rehabilitation strategies for people after surgical reconstruction of the joints or construct robotic joints replacement for medical purposes. The aim of this research is to investigate the effect of long-distance running on the ankle and knee complex by using a subject-specific computational model combined with MRI. Through this collaborative research between medical sciences and bioengineering, we expect that our work will impact a number of research communities in Medicine and Engineering.


This study is open to and in aged 18 to 50
Healthy volunteers included

Am I eligible to participate?

You are eligible to participate in this study if you are Caucasian and either a novice (beginner) runner or a marathon experienced runner.

·        You  need to complete a 21 km running on a treadmill

·       For novice runners, you have never participated a half- or full-marathon in your life

·      For marathon experienced runner, you have regularly participated in a half- or full-marathon at least one time for the last three years

·         You are aged between 18- and 50-year-old

·         You are able to give informed consent

·         You have no injury or any surgery of the lower extremity

·         You have normal BMI ranges between 18 and 30

·         You do not have contraindication to MRI

We will ask you some more questions about your training experiences, activity level, or about past injuries and let you know if you can be a participant.